In the gluten-sensitive enteropathy celiac disease (CeD), production of autoantibodies against the enzyme transglutaminase (TG) 2 is explained by a hapten-carrier-like model, where TG2-specific B cells bind complexes of TG2 and gluten, allowing interaction with gluten-specific CD4+ T cells4. The gene discussed is TGM2; the disease is cranioectodermal dysplasia.