In addition, IFNγ, by upregulating interferon-regulatory factor 1 (IRF1) and downregulating the expression of SLC7A11 and SLC3A2, modulated the function of system Xc-, leading to tumor cell ferroptosis via the Janus kinase (JAK) and signal transducer and activator of transcription 1 (STAT1) signaling pathway within tumor cells. Here, STAT1 is linked to neoplasm.