Trans-chalcone is an antioxidant with anti-inflammation property, which can increase p53 activity and decrease \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β-catenin expression to induce an autophagy cell death in hepatocellular carcinoma (HCC) [133]. Here, TP53 is linked to hepatocellular carcinoma.