As NSD3 has been identified as oncogenic in multiple cancers, the associated INV is classified here as unlikely pathogenic, with all remaining pLoF INVs classified as PP-SVs, as they disrupting known to PCa and Lynch Syndrome predisposing DNA mismatch repair gene MLH1 and PCa tumour suppressor genes RB1, WASF1, and FOXP1 (Supplementary Table 7). The gene discussed is NSD3; the disease is Lynch syndrome.