A potentially pathogenic INV, previously reported at MAF of 9.6e-05 in Africans and resulting in NR2E1-WASF1 fusion, was identified in a single African patient presenting at 70 years of age with ISUP GG5 PCa, showed 14 supporting read-pairs (Supplementary Fig. 14), with somatic hyper-amplification during tumourigenesis. The gene discussed is NR2E1; the disease is posterior cortical atrophy.