MLH1 and Lynch syndrome: As NSD3 has been identified as oncogenic in multiple cancers, the associated INV is classified here as unlikely pathogenic, with all remaining pLoF INVs classified as PP-SVs, as they disrupting known to PCa and Lynch Syndrome predisposing DNA mismatch repair gene MLH1 and PCa tumour suppressor genes RB1, WASF1, and FOXP1 (Supplementary Table 7).