While a paediatric cancer predisposing tumour suppressor gene commonly mutated in retinoblastoma and to a lesser extent osteosarcoma63, and less common as an adult cancer predisposing gene64, Retinoblastoma transcriptional corepressor 1 (RB1) is recognised as one of five most prevalent somatically mutated genes in metastatic cancers65, with RB1 loss in prostate tumours associated with poor patient outcomes66. This evidence concerns the gene RB1 and prostate neoplasm.