Reported to be downregulated in numerous cancer types (all-type p-value < 0.001, GENT2 T-test), although not significant for PCa, pLoF deletion of the pigmentation gene OCA2 has been linked not only to Prader-Willi syndrome, but also Prader-Willi associated malignancies34, and melanoma35, with recent studies linking melanoma with increased PCa risk36. This evidence concerns the gene OCA2 and Prader-Willi syndrome.