MLH1 and posterior cortical atrophy: While PCa patients presenting with pathogenic MLH1 mutations were reported to have significantly higher disease burden for African Americans24, here we found a dbVar known MLH1 pLoF INV with around 11 supporting short read-pairs (Supplementary Fig. 12) in a 64-year-old African male presenting with ISUP GG4 at diagnosis and at the time of diagnosis no somatic LOH or a second gene hit.