In this study, we proved that specific cytokines and chemokines, such as EGF, CXCL1, CCL17, CCL5, CXCL12, IL-2, IL-8, are expressed in PAs/PitNETs and act modulating pattern of growth and proliferation: higher expression of EGF, CXCL1, CCL17 and lower expression of IL-2 were identified in invasive PAs/PitNETs. This evidence concerns the gene EGF and gonorrhea.