EGFR and cancer: This high variation is affected by various factors such as the histopatholgical type of cancer, the presence status of the epidermal growth factor receptor (EGFR) mutation/wildtype, and the actual stage of disease (Berghoff et al. 2016; Nayak et al. 2012; Goncalves et al. 2016; Wang et al. 2017; Zhang et al. 2020; Rizzoli et al. 2013).