However, another study identified 40 non-synonymous variants by sequencing, of which the combined burden of rare variants (minor allele frequency [MAF] <0.1%), particularly the variants impairing MT2 signalling, was associated with elevated type 2 diabetes prevalence (N=7632 European individuals, 2186 with type 2 diabetes) [14]. The gene discussed is MTNR1B; the disease is type 2 diabetes mellitus.