In addition, we have shown that gene expression profiles from our mouse models of AxD are highly congruent with a transcriptomic portrait of human Alzheimer's disease, second only to the Alzheimer's APP/PSEN1 mouse in comparison with large-scale gene expression data from over 500 animal models (Gammie et al., 2024). Here, PSEN1 is linked to early-onset autosomal dominant Alzheimer disease.