Transcripts related to cellular senescence and p53 signaling, including Cdnk1a (p21WAF), cyclins and checkpoint kinases, GADD45 genes, and Tp53 itself, were also significantly enriched, corroborating our recent work showing astrocyte senescence in the rat as well as other models of AxD (Wang et al., 2022). Here, TP53 is linked to Alexander disease.