FH and cancer: Patient 6, a 59-year-old female with a history of endometriosis and possible fibroids, for which she underwent total abdominal hysterectomy and bilateral salpingo-oophrectomy years prior to presentation, presented with (1) a substitution in VHL (c.598C>T, p.R200W, aforementioned Chuvash variant) and (2) a likely pathogenic variant in FH (c1431_1433dup, pLys477dup) after seeking cancer genetic testing given a second-degree relative had early-onset breast cancer (Multi-Cancer Panel, Invitae Genetics).