FH and hereditary leiomyomatosis and renal cell cancer: Germline FH pathogenic variants are linked to the development of Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) disease.4 However, this specific variant has not been unequivocally linked to HLRCC risk,5 although we need more definitive and confirmatory data to definitely conclude the risk for HLRCC for this variant.