S100B and Cognitive impairment: While the differential expression of S100B in MCI and DAT patients compared to that of healthy controls clearly highlights the role of S100B as a diagnostic molecular marker for cognitive impairment, SPARC behavior, given its protective effects on cell viability, represents a sort of therapeutic marker, overexpressed in DAT, compared to MCI patients, just as it would represent a brain attempt (with reverberation in the peripheral blood) to protect or save cell nerves from neuroinflammatory damage.