TGFB1 and brain neoplasm: Brain tumor angiogenesis, which is closely associated with brain tumor progression, is mediated through the action of many angiogenic factors including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF), and TGF-β, MMPs, and angiopoietins (Angs) [4].