For example, mutations in Lars2, the mitochondrial leucyl-tRNA synthetase, is associated with premature ovarian failure in women (Pierce et al., 2013) and aberrant methylation at the promoter of Mgmt, a gene that is required for DNA repair and linked to the formation of testicular germ cell tumors in humans (da S Martinelli et al., 2017). This evidence concerns the gene LARS2 and primary ovarian failure.