GFRAL and Obesity: These drugs inhibit cellproliferation by trapping replication or transcription machinery (55) and induce apoptosis through aROS-dependent DNA damage signalling pathway (56,57).Camptothecin, a topoisomerase inhibitor, effectively treats obesity in mice byactivating glial-derived neurotrophic factor (GDNF) receptor alpha-like (GFRAL)(58).