In addition, in a cell communication analysis of scRNA‐seq data of the dynamic evolution from precancerous lesions to invasive lung adenocarcinoma, it was shown that no communication between cancer cells and TME cells through TGF‐β signaling was observed in adenocarcinoma in situ and microinvasive adenocarcinoma, but this interaction was significantly enhanced in invasive adenocarcinoma, especially in NK, hypertrophic and MALT B cells. The gene discussed is TGFB1; the disease is adenocarcinoma.