CD44 and neoplasm: Using CellPhoneDB28 to analyze cell communication by searching for ligand–receptor interactions between malignant cells (ligand source) and T cells (receptor source), it was revealed that SPP1‐CD44 is the top interaction pair between malignant cells and T cells, further supporting the key role of SPP1 in the tumor ecosystem and suggesting that the TME is polarized as tumor branches evolve [89, 144].