As has been reported, RIP1 plays a core role in inflammation, apoptosis, and necroptosis, and is widely involved in the pathogenesis of various diseases, including multiple sclerosis [15], amyotrophic lateral sclerosis [16], alzheimer's disease [17, 18], Niemann‐Pick disease [19] and hereditary retinal degeneration [20],cancer(acute myeloid leukemia, breast cancer and colorectal cancer) and so on [21, 22]. The gene discussed is RIPK1; the disease is early-onset autosomal dominant Alzheimer disease.