Genuinely, advanced liver fibrosis is illustrated by the constant activation of immune system cells by pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) that enhance the release of cytokines and chemokines which are precursors of developing inflammation.31,32 Ibáñez-Samaniego et al showed a positive correlation between FIB-4 and CRP that further supports the mentioned hypothesis.24 The gene discussed is CRP; the disease is Hepatic fibrosis.