[177] utilized snRNA-seq, snATAC-seq, and spatial transcriptomics to uncover the phenotypic regulatory dynamics of vascular smooth muscle cells (VSMCs) in aortic root aneurysms of Marfan syndrome (MFS) patients, identifying FOXN3 and other regulatory factors as critical for maintaining the contractile phenotype of VSMCs. Here, FOXN3 is linked to Marfan syndrome.