He et al. (2024) reported that AQP4 is also involved in the morphological changes that occur after astrocyte activation. Aurora kinase B (AURKB) regulates the phosphorylation of nuclear factor of activated T cells 5 (NFAT5) and promotes its translocation into the nucleus, thereby stimulating AQP4 expression after peripheral nerve injury (He et al., 2024). The gene discussed is NFAT5; the disease is peripheral nerve injury.