6MWTD: 6-minute walk test distance; GLP-1: glucagon-like peptide-1; HFpEF: heart failure with preserved ejection fraction; HFrEF: heart failure with reduced ejection fraction; KCCQ: Kansas City Cardiomyopathy Questionnaire; SGLT-2: sodium-glucose cotransporter-2. The gene discussed is GCG; the disease is heart failure.