B: Benefits; R: Risks; GLP-1 RA: Glucagon-like peptide-1 receptor agonist; CVD: Cardiovascular disease; HF: Heart failure; HHF: Heart failure hospitalization; CVOTs: Cardiovascular outcome trials; MACE: Major Adverse Cardiovascular Events; KCCQ-CSS: Kansas City Cardiomyopathy Questionnaire Clinical Summary Score. This evidence concerns the gene GLP1R and hydrops fetalis.