B: Benefits; R: Risks; GLP-1 RA: Glucagon-like peptide-1 receptor agonist; iNKT cells: invariant natural killer T cells; PASI: Psoriasis Area and Severity Index; T2DM: Type 2 Diabetes Mellitus; DQLI: Dermatology Quality of Life Index; HbA1c: Hemoglobin A1c; BMI: Body Mass Index; IL-17: Interlukin-17. This evidence concerns the gene GCG and diabetes mellitus.