Decreased BMI, waist circumference, visceral adipose tissue, fasting and post-OGTT, and increased SHBG. Improved insulin sensitivity leads to balanced secretion of LH and ovarian androgens restoring some ovarian and endometrial function. A 69.2% of previously infertile patients were pregnant within 1 year either spontaneously or IVF procedures. The gene discussed is INS; the disease is Infertility.