In their retrospective study of patients with SOD, Cemeroglu et al. found that 96% of patients had MRI evidence of optic nerve hypoplasia, a multitude had MRI evidence of midline brain abnormalities including 85% of patients with absent/hypoplastic septum pellucidum, and 32% with absent/hypoplastic corpus callosum [4]. The gene discussed is SOD1; the disease is Autosomal dominant optic atrophy, classic type.