SP1 and cancer: GSEA also showed significant enhancement of cancer copy number (the top 5 enriched gene sets: SP1, CHD1, KAT6, EP300, CREBBP), inflammatory response (the top 5 enriched gene sets: IL1B, CXCL8, COX2, NFKB1, STAT1), cytokine receptor interactions (the top 5 enriched gene sets: IL2, IFNG, CSF2, IL2RA, IFNGR1), and TCR signaling pathways (the top 5 enriched gene sets:ZAP70, LCK, LAT, PIK3R1, AKT1) (Figures 5I–L).