MFAP4 and central nervous system cancer: To further understand the effect of MFAP4 on TME, we further investigated the possible role of MFAP4 in gliomas using GSEA and GO analyses, which showed that it is involved in multiple immune-related pathways including leukocyte migration, T cell activation, cytokine receptor interaction and chemokine receptor binding, which suggests that MFAP4 may regulate the tumor micro environment affecting the level of immune infiltration and thus drug resistance in glioma patients.