Impact on the tumor microenvironment (TME), high expression of IFIT3 is associated with poor prognosis in acute myeloid leukemia (AML)/IFIT1/IFIT3 inhibits Bcl-2 through pyroptosisIn acute promyelocytic leukemia (APL), the PML-RAR fusion protein inhibits the RIG-G (i.e. IFIT3) expression and inhibits disease progression. The gene discussed is PML; the disease is acute promyelocytic leukemia.