PPARG and colitis: Additionally, exacerbation of existing physiological disorders has also been reported by Zheng et al. Their observations involving mice with induced ulcerative colitis included amplified inflammation marked by increased levels of IL-1β, TNF-α and IFN-γ; promotion in the differentiation of adipocytes; increased peroxidation levels of liver lipids and enhanced liver metabolic disorders in mice with colitis marked by the accumulation of triglycerides and elevated levels of malondialdehyde and peroxisome proliferator-activated receptor gamma (PPAR-γ) [125].