SMAD4 and cancer: They are modulate cancer proliferation and growth by downregulation of FLOT-2, MEK/ERK1/2, FGFR, PI3K/AKT, TRIM44, FLSs-RA, TGF-β1/Smad4, CCND1, CCNE2, CDK1, CDK4, CDK6, CDC25C, CHEK1,ANLN and VEGFA and upregulation of PTEN.