BCL2 and B-cell chronic lymphocytic leukemia: miR-16-1 has a role in suppressing tumors in various malignancies such as chronic lymphocytic leukemia (CLL) by modulating molecules including B-cell lymphoma 2 (BCL2), Wnt, CCND, etc. In eukaryotic cells, BCL2 inhibits the death of cells and promotes cell survival too.