CDK4 and breast cancer: For example, its overexpression can affect the axes miR-193a-5p/HMGB1/PI3K/AKT in breast cancer (11), miR-338-3p/HIF-1α in cervical (17), miR-637/STAT3/Bcl-2/beclin1 in colorectal (19), miR-124/B4GALT1, NF-κB in chronic myeloid leukemia (23), miR-124-3p/STAT3 in glioma (38), miR-124/SphK1/STAT3/CDK4 in lung (48), miR-215–5p/YY1 in melanoma (54) and miR-7/VEGF in ovarian (62), contributing to cancer cell growth, proliferation, invasion, migration, epithelial-mesenchymal transitions, apoptosis inhibition, and chemoresistance.