Indeed, circHIPK3 contributes to hyperglycemia and insulin resistance by disturbing the miR-192-5p/FOXO1 axis homeostasis (99) and is upregulated in type II diabetes patients (100), and it was found upregulated in acute pancreatitis (101), an important risk factor for the pancreatic cancer development (102). Here, FOXO1 is linked to acute pancreatitis.