NXPH4 and urinary bladder cancer: Therefore, the ROS-induced NXPH4/↓circHIPK3/↑miR-29b-3p/↑miR-193a-3p/↓LOXL4/↓SRSF2 axis may represent a potential mechanism through which circHIPK3 downregulation contributes to gemcitabine resistance in bladder cancer.