Temozolomide resistance arises as a consequence of the modulation of the cell concentration (IC50) of temozolomide and apoptosis inhibition by circHIPK3/miR-524-5p/KIF2A (41) and exosomal-circHIPK3/miR-421/ZIC5 (42) axis regulation in glioblastoma. This evidence concerns the gene ZIC5 and glioblastoma.