CDH1 and gastric cancer: Nevertheless, due to the limited understanding of GC pathogenesis and the shortage of targeting therapy, available remedies like chemotherapy and surgical operation do not satisfactorily improve the survival rate of GC patients (2), although some studies have indicated that Her2, E-cadherin, fibroblast growth factor receptor as well as microRNAs, and long noncoding RNAs, can be GC markers (3).