Correlation analysis revealed that certain laboratory indicators lactic acid dehydrogenase (LDH), albumin (ALB), creatine kinase (CK), troponin T (TnT), N-terminal pro-brain natriuretic peptide (NT-proBNP) and fibrin degradation product (FDP), which exhibited significant differences between groups, were significantly correlated with COVID-19-related mortality (all P<0.05). The gene discussed is NPPB; the disease is COVID-19.