PPARA and bacterial infectious disease: Furthermore, systemic Pparα knockout mice demonstrate heightened mortality following bacterial infection (Paumelle et al., 2020).In animal studies, LPS has been shown to reduce the levels of both PPAR-α and PPAR‐y co‐activator (PGC)‐1α (Van Wyngene et al., 2018), contributing to the disruption of β-oxidation and the incidence of lipotoxicity, resulting in further liver damage.