PPARA and Sepsis: In sepsis, excessive inflammasome activation and cellular pyroptosis are linked to liver injury (Coll et al., 2015).PPARα is a transcription factor crucial for the catabolism of free fatty acids; during sepsis, diminished expression of PPARα results in the accumulation of free fatty acids in the blood and liver, leading to cytotoxicity (Vandewalle et al., 2022).