While the two biomarkers are positively correlated (r = 0.35, P < 2.2e-16), both remained independently associated with all-cause dementia when they were jointly analyzed in a multiple logistic regression model including all four genetic variants APOE4, APOE2, TREM2 R47H and R62H (Table 1; Supplementary Table 1). The gene discussed is APOE; the disease is dementia.