CP and early-onset autosomal dominant Alzheimer disease: Indeed, CP integrity is believed to play a significant role in cognition, as increasing research indicates that an enlarged CP is often associated with cognitive impairment in a myriad of conditions including mild cognitive impairment (9), Alzheimer’s disease (AD) (10, 11), Parkinson’s disease (PD) (12, 13), and multiple sclerosis (MS) (14, 15), where CP size correlates with the severity of cognitive decline.