While direct evidence for elevated FWF in older individuals with DS is insufficient, increased FWF has been documented in older adults with AlzD.58,59 DS is associated with early onset and increased prevalence of AlzD, purportedly due to the triplicated amyloid precursor protein on chromosome 21.5,60,61 Thus, increased FWF in older DS individuals may reflect neurodegeneration or inflammation similar to that seen in AlzD. Here, APP is linked to Dravet syndrome.