DHODH and cancer: Limited studies have investigated the role of these nucleotides on PCa development; however, dihydroorotate is essential in the de-novo synthesis of pyrimidine and is the substrate for the enzyme dihydroorotate dehydrogenase (DHDOH), the inhibition of which is a potential target for cancer therapy due to the role of pyrimidines in RNA/DNA synthesis and cell proliferation61.