IGHE and Herpesviridae infectious disease: One such factor that could not be fully ruled out is Capping Protein Regulator and Myosin 1 Linker 2 (CARMIL2) deficiency, a condition in which patients typically present with high IgE levels, elevated eosinophils, severe eczema, warts (human papilloma virus and molluscum), Herpesviridae infections, eosinophilic gastrointestinal disease, inflammatory bowel disease, asthma/bronchiectasis, and EBV-associated malignancies.