In our lymphoma-on-chip model, we detected IL-6 in the luminal supernatant when FRCs were present in the hydrogel, and IL-6 levels increased when both FRCs and DLBCL cells were present, supporting the hypothesis that FRCs are the source of high IL-6 levels in DLBCL. This evidence concerns the gene IL6 and diffuse large B-cell lymphoma.