However, as also reported by others [9], Vimentin+ LNSCs are still present in between the tumor cells (Fig. 1A), and this can be mimicked in vitro by co-culture of DLBCL tumor cells (human DLBCL cell line OCI-Ly18) and primary human FRCs in a collagen hydrogel, where the Vimentin+ FRCs are localized within and around clusters of DLBCL cells (Fig. 1B). The gene discussed is VIM; the disease is neoplasm.