Thus, in human, it has been reported related to TNF release in patients affected by hepatocellular carcinoma (HCC), while in animal models, where the phenomenon has been more extensively studied, it has been linked in turn to cytokine release, macrophagic activation, miRNA-194, oxidative stress, DNA repair, phagocytic cells increased activity, and others [13–15]. Here, TNF is linked to hepatocellular carcinoma.