Colorectal cancers without APC alterations constituted 26% of the cases in the colorectal cancer TCGA cohort and among them, 44 cases (8.2% of the entire cohort) had alterations in RNF43, CTNNB1, or TCF7L2 (termed triple altered cohort) and 95 cases (17.8% of the entire cohort) had no alterations in RNF43, CTNNB1, and TCF7L2 (quadruple wild type cohort). Here, TCF7L2 is linked to colorectal cancer.