For instance, tissue apical exposure to Chlorocresol failed to induce a CBF decrease in MucilAirTM-HF tissues, and LPS via apical exposure did not trigger intense inflammatory cytokine secretion in EpiAveolar model, whereas a mild response was observed in MucilAirTM-HF tissues exposed to TNF-α and LPS (at 6h/day aerosol exposure only); on the other hand, no effects were triggered by Nicotine and Sulforaphane, both via aerosol exposure, similar to other in vitro systems (see details in Supplementary Table S1). Here, TNF is linked to hydrops fetalis.