Several forms of demyelinating CMT are caused by mutations in genes encoding proteins involved in membrane dynamics and endosomal trafficking, includingN-myc downstream regulated gene 1(NDRG1), myotubularin related protein 2(MTMR2), SET binding factor 2 (SBF2/MTMR13),SH3 domain and tetratricopeptide repeats 2(SH3TC2), dynamin 2 (DNM2), FIG4 phosphoinositide 5-phosphatase (FIG4), andLPS-induced TN factor(LITAF/SIMPLE) (reviewed in(Markworth et al., 2021)). The gene discussed is SBF2; the disease is Charcot-Marie-Tooth disease.