AKT1 and glioblastoma: It has been shown that TBMS1 reduces cyclin B1, CDK1, and AKT phosphorylation levels and elevates the level of the cKd1 inhibitor p21, which inhibits DNA synthesis and induces G2/M phase block in glioblastoma cells by targeting the PI3K/AKT/p21 and p21/CDK1/cyclin B1 signaling cascades (Cao et al., 2020).