PIEZO1 and glioblastoma: Knockdown of Piezo1 expression by doxycycline-induced Piezo1 shRNA could be observed after treatment of glioblastoma model mice with doxycycline, which significantly suppressed GBM tumor growth and prolonged the survival time of the mice, suggesting that Piezo1 is critical for the maintenance and progression of glioblastomas once tumors form (Chen et al., 2018).