Tumor tissue sclerosis provides a mechanistic microenvironment for the activation of Piezo1, which promotes adhesion plaque assembly and activates the β1-integrin-FAK signaling pathway, regulates cell proliferation and participates in extracellular matrix remodeling, which further regulates tissue stiffness and the stiffer environment further enhances Piezo1 expression, which increases mechanosensory and mechanotransduction capacities of tumor cells (Chen et al., 2018). The gene discussed is PTK2; the disease is neoplasm.