On the other hand, ROS generated by ultrasound-activated intracellular ultrasound sensitizers prolonged the opening time of Piezo1 and promoted Ca2+ entry into the cell to bind to lipid droplets to form complexes, thereby affecting lipid metabolism and preventing it from providing energy to glioblastoma cells, leading to cell death (Chen et al., 2022). The gene discussed is PIEZO1; the disease is glioblastoma.