It has been shown that glioblastoma cells use piezo1 channels to sense mechanical stimuli from the tumor microenvironment and deform the cell membrane (stretching, indentation, invagination, etc.), inducing an increase in cytoplasmic Ca2+ through, for example, activation of KCa channels and modulation of actin cytoskeletal polymerization, which allows for a change in the volume and shape of the cells required to invade healthy brain parenchyma. Here, CSN3 is linked to glioblastoma.