Furthermore, many signaling pathways such as matrix metalloproteinase (MMP) family, tissue inhibitor of metalloproteinases (TIMP) family, mitogen-activated protein kinase (MAPK) family, phosphoinositide 3 kinase (PI3K) family, and others are positively correlated with high expression of Piezo1 during the pathology of glioblastoma development. This evidence concerns the gene WNK2 and glioblastoma.