Among these genes, TIMP1, MAPK13, MAPKAPK2, and MAPKAPK3 regulate cell proliferation, PLOD1, MMP14, ADAM9, and PLAU control ECM remodeling, MMP2, and MMP9 control tumor-associated tissue remodeling; PIK3CD is involved in immune response, AKT2 regulates tumorigenesis, FHL3 controls actin cytoskeleton, and TAZ regulates the mechanosensitive HIPPO signaling pathway (Figure 4). Here, PIK3CD is linked to neoplasm.