Several studies have demonstrated that Piezo1 affects several underlying pathophysiological processes such as tissue hardening, angiogenesis, energy supply, and immune cell infiltration in glioblastoma, and can be used as an indicator of malignancy and prognostic assessment of glioblastoma patients, as well as a therapeutic target for controlling tumor progression (Figure 7). The gene discussed is PIEZO1; the disease is neoplasm.