FAK activation promotes tumor growth, invasion, metastasis, and angiogenesis through kinase-dependent (such as PI3K/AKT signaling pathway, P53 signaling pathway, RAS/RAF/MEK/ERK signaling pathway, YAP signaling pathway) and kinase-independent pathways (e.g., inhibition of T-cells, B-cells, and dendritic cells in the immune microenvironment. The gene discussed is PTK2; the disease is neoplasm.