Src complex and causes phosphorylation of Paxillin and clustered regularly interspaced shortpalindromic repeats (CRISPR)-associated systems (Cas), which activate mitogen-activated protein kinase (MAPK), a kinase downstream of the rat sarcoma (Ras) pathway, via the junction proteins cysteine-rich receptor-like protein kinases (Crk) and growth factor receptor-bound protein 2 (Grb2) to control lesion adhesion and cytoskeleton assembly, regulate extracellular matrix remodeling, and increase the stiffness of glioblastoma tissues. Here, GRB2 is linked to glioblastoma.