Meanwhile, studies have shown that inhibition of Piezo1 further increases the expression of P-JNK1 (T183/Y185), promotes the expression of pro-apoptotic proteins such as c-Jun N-terminal kinase (cJUN), Bcl2-associated X (BAX), etc., inhibits tumor cell proliferation, and induces apoptosis of glioma cells (Liu et al., 2019). Here, PIEZO1 is linked to central nervous system cancer.