In addition, aberrant expression of lncRNAs like HOTTIP (Luo et al., 2022), epigenetic like m6A methylation (Hwang et al., 2024), and transcriptional regulators like SRSF2 and U2 small nuclear RNA auxiliary factor 1 (U2AF1) can lead to abnormally elevated levels of R-loops and ultimately to blood disorders (Pellagatti and Boultwood, 2020). Here, U2AF1 is linked to hematologic disorder.