Dead-box helicase 41 (DDX41), a helicase, not only unwinds DNA-RNA hydrids but also activates the cGAMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway in blood disorders (Winstone et al., 2024; Smith et al., 2023). The gene discussed is DDX41; the disease is hematologic disorder.