RYR1 and hydrops fetalis: In 327 HF patients, decreased mortality risk was associated with two RYR1 SNPs: rs12974674 (HR: 0.59; 95% CI: 0.40–0.87; P = 0.007) and rs2915950 (HR: 0.62, 95% CI: 0.43–0.88; P = 0.008).