These distinctions extend to their associated disorders, with RYR2 mutations linked to cardiac arrhythmias such as catecholaminergic polymorphic ventricular tachycardia, while RYR1 mutations are typically associated with malignant hyperthermia and muscular pathologies (13, 43, 44). Here, RYR1 is linked to catecholaminergic polymorphic ventricular tachycardia.