While our primary analysis in the UIC-HF population suggested the RYR1 SNP associations were present in a racially diverse patient population, the non-significant associations we observed in the non-Black subgroup in the sensitivity analysis likely indicate that either the smaller subgroup had less power to detect effects, or the role of RYR1 in HF progression may be more pronounced in patients of African descent. The gene discussed is RYR1; the disease is hydrops fetalis.