Three patients in the ESTAND cohort had findings in pleiotropic genes SPRED1, NF1, and LZTR1 linked to developmental syndromes referred to as RASopathies, including various cancerous and non-cancerous tumors as part of the respective syndromic phenotype (Juchnewitsch et al., 2024). The gene discussed is NF1; the disease is RASopathy.