CHEK2 and cancer: Additionally, we analyzed known risk variants for cancer susceptibility in Central and Eastern Europe, CHEK2 p.Ile157Thr (population prevalence in Estonia 8.6%), CHEK2 p.Thr367fs (0.6%), and CHEK2: c.319 + 2T>A (0.1%) (Pavlovica et al., 2022).