Moreover, since some hereditary cancer syndromes tend disproportionately to affect female family members (e.g. BRCA1, BRCA2, PALB2 variants and breast cancer; National Comprehensive Cancer Network, 2024), Lynch syndrome and endometrial cancer (Lu and Broaddus, 2020), cascade screening among family members will offer apparent clinical benefits. Here, BRCA1 is linked to Lynch syndrome.