Moreover, since some hereditary cancer syndromes tend disproportionately to affect female family members (e.g. BRCA1, BRCA2, PALB2 variants and breast cancer; National Comprehensive Cancer Network, 2024), Lynch syndrome and endometrial cancer (Lu and Broaddus, 2020), cascade screening among family members will offer apparent clinical benefits. This evidence concerns the gene BRCA2 and Inherited cancer-predisposing syndrome.