Mutant mouse models for Atm, Bard1, Brca1, Brca2, Brip1, Fancm, Mlh1, Nf1, Palb2, Rad51C, Smad4, Tp53, Tsc1, Tsc2, and Wt1 have been reported to exhibit male sub- or infertility, abnormal male meiosis, congenital gonadal dysgenesis, and/or gonadal atrophy. This evidence concerns the gene SMAD4 and Infertility.