Moreover, since some hereditary cancer syndromes tend disproportionately to affect female family members (e.g. BRCA1, BRCA2, PALB2 variants and breast cancer; National Comprehensive Cancer Network, 2024), Lynch syndrome and endometrial cancer (Lu and Broaddus, 2020), cascade screening among family members will offer apparent clinical benefits. The gene discussed is BRCA1; the disease is endometrial cancer.