Six infertile men presented a history of cancerous or non-cancerous tumors—leiomyosarcoma (BRCA2 p.Ser599Ter), lymphoma (TP53 p.Arg181His), basalioma (WT1 p.Trp151Gly), fibroma and renal cysts (TSC1 p.Ala428fs), neoplasms of uncertain behavior (PHOX2B p.Phe33fs), and schwannomatosis (LZTR1 p.Arg283Gln) (Table 2). The gene discussed is LZTR1; the disease is leiomyosarcoma.