Several genes critical in repairing DNA double-strand breaks (DSB) have been linked to hereditary cancer syndromes and infertility in both men and women (e.g. BRCA2, FANCM, XRCC2) (Kasak et al., 2018; Tsui and Crismani, 2019). Here, BRCA2 is linked to Inherited cancer-predisposing syndrome.