The following genes were thus identified: Igfbp5 (encoding insulin-like growth factor binding protein 5), Cd34 (encoding cluster of differentiation 34), Mertk (encoding MER proto-oncogene tyrosine kinase), and Ace (encoding angiotensin-converting enzyme), which were down-regulated in lymphedema, and Lck (encoding lymphocyte cell-specific protein-tyrosine kinase) and Egln1 (encoding Egl-9 family hypoxia inducible factor 1), which were up-regulated (Figure 1C). The gene discussed is IGFBP5; the disease is lymphedema.