The transcriptional program in antigen-activated ocular CD4 T cell also overlapped with other antigen-driven inflammatory diseases including allograft rejection, type 1 diabetes, graft vs. host disease and systemic lupus erythematosus (Figure 2H), suggesting that ocular CD4 T cells share pathologic features with CD4 T cells in other autoimmune diseases. Here, CD4 is linked to systemic lupus erythematosus.