HLA-C and Behcet disease: Nevertheless, the coexistence of myeloid-rich infiltrates and antigen-activated T cells in both HLA-B27 AAU and Behcet’s disease supports their designation by the EULAR study group as MHC-opathies, diseases in which polymorphisms in antigen presentation genes are hypothesized to predispose patients to tissue inflammation driven by presentation self-peptides by myeloid cells to CD8 T cells.52