It has been reported that brassinosteroids decreasecell proliferationand induce apoptosis in colon cancer cell lines; e.g. the administrationof epibrassinolide (4) (Figure 4B) reduced the volume and diameter and causedcell cycle arrest of colon tumor cells in mouse xenograft models whenapplied in a dose-dependent manner.22 Inneuroblastomas, it was able to induce apoptosis by interfering withthe phosphorylation of GSK3β and preventing the translocationof β-catenin.23 Here, GSK3B is linked to colonic neoplasm.