ESR2 and non-small cell lung carcinoma: It has been reported that a combination of 17β-estradioland progesterone has a synergistic anticancer effect on colorectalcancer in male mice; this effect is possibly related to ERβ,ERα, and PGR-mediated pathways.77 Corticosteroids, on the other hand, have recently been related topoor outcomes when coadministered in non-small-cell lung cancer patientsunder immunotherapy.78 The same resultswere observed79 when administering highdoses of corticosteroids in melanoma, non-small-cell lung cancer,and renal carcinoma patients under anti-PD1 therapy.