A different type of digestive system cancer wasstudied.48 Employing colorectal cancer,it was found thatβ-sitosterol (15) (Figure 14) can recover oxaliplatin sensitivity indrug-resistant colorectal cancer by inhibiting the expression of BCRP.This study also demonstrated that the p53 pathway is also affected,being capable of disrupting the p53-MDM2 interaction and causing theinhibition of the NF-κB factor. This evidence concerns the gene TP53 and digestive system cancer.