A key immune checkpoint molecule involved in GBM immunity escape is PD‐L1, expressed on GBM tumor cells, microglia, and TAM, binds to PD‐1 to downregulate the T‐cell mediated immune response, thereby suppressing the proliferation and function of cytotoxic T cells and promotes T‐reg activity.181, 182. The gene discussed is CD274; the disease is glioblastoma.