MAPT and Cognitive impairment: Figure 6 and S8 Table show the comparisons of demographics, HIV-related parameters, biomarkers, and neurocognitive metrics between clusters. Among the differences, C2 had the highest prevalence of female sex, and levels of CD4+ T cells and astrocytosis (S100β protein). C3 had the lowest levels of all CSF biomarkers, with total tau, Aβ42, and leukocytes reaching statistical significance. None of the members of C3 had cognitive impairment (versus 56% in C2, p=0.005, and 32% in C1, p=0.048), attaining the best scores in all cognitive domains (Figure 6; S8 Table).