SOD1 and amyotrophic lateral sclerosis: Unexpectedly, abundance map scores did not correlate with patient SOD1 protein abundance measurements, despite showing strong positive correlation with mouse protein half-life37,87; Low SOD1 protein half-life has been attributed to increased chaperone-assisted autophagy, leading to chaperone exhaustion, higher levels of misfolded SOD1, and ALS onset88,89.