Analysis of gene expression in our single-cell BCC data revealed several targetable Gαs-coupled GPCRs present in tumor cells, including prostaglandin E receptor 4 (Ptger4), adenosine receptor 2b (Adora2b) and β-Adrenergic Receptors (Adrb1–2), among others (Fig. 6D). This evidence concerns the gene ADORA2B and neoplasm.