To study the role of nuclear PDGFB in glioma progression, we developed a new model of immunocompetent glioma using in utero electroporation (IUE) of piggyBac transposase driving GFP and PDGFB overexpression (PDGFBwt) in neural progenitor cells (Figs. S1e–f). Here, PDGFB is linked to central nervous system cancer.