To elucidate how the presence of PDGFB in the nucleus impacts the chromatin landscape, we performed single cell RNA sequencing (scRNA-seq) and single cell transposase-accessible chromatin with sequencing (scATAC-seq) on PDGFBΔNLS, PDGFBwt and non-tumor mouse brains (Figs. S3e–f). Here, PDGFB is linked to neoplasm.